Crystal structure of Dot1L in complex with an inhibitor (compound 3).
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Crystal structure of Dot1L in complex with an inhibitor (compound 3). Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, ~{N}1-[(~{S})-(3-chlorophenyl)-pyridin-2-yl-methyl]-4-methylsulfonyl-~{N}2-pyrimidin-2-yl-benzene-1,2-diamine Authors: Scheufler, C, Stauffer, F, Be, C, Moebitz, H. Deposit date: 2019-11-11 Release date: 2019-12-11 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.98 Å) Cite: New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10, 2019
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2019-11-11
