Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) gener

NIAID Data Ecosystem60

Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins

线粒体动力学

蛋白质相互作用调控

Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change. Pertu

Figshare2016-01-18 更新40

Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1β

线粒体动力学

基因表达调控

BackgroundThere is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression.

NIAID Data Ecosystem70

Mitochondrial fragmentation and network architecture in degenerative diseases

线粒体动力学

神经退行性机制

Fragmentation of mitochondrial network has been implicated in many neurodegenerative, renal, and metabolic diseases. However, a quantitative measure of the microscopic parameters resulting in the impa

NIAID Data Ecosystem40