Complex of human thrombin (S195A) bound to a bivalent inhibitor comprised of DNA Aptamer HD22 conjugated to Dabigatran with a linker.

Complex of human thrombin (S195A) bound to a bivalent inhibitor comprised of DNA Aptamer HD22 conjugated to Dabigatran with a linker. Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (30-MER), ... Authors: Krishnaswamy, S, Kumar, S. Deposit date: 2023-08-08 Release date: 2024-05-01 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.207 Å) Cite: Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors. Nat Commun, 15, 2024