Thione-Directed C–H Amidation of Chromone Analogues with Dioxazolones under Rh(III) Catalysis

Sulfur-containing organic molecules are recognized as
promising
candidates for catalytic C–H functionalization and medicinal
chemistry owing to the exceptional ability of the sulfur atom to bind
to transition metals and target enzymes. In this study, we report
the Rh(III)-catalyzed thione-directed C–H amidation of various
thiochromone analogues derived from flavones, isoflavones, and xanthones.
Post-transformations of C5-amidated thiochromone products were investigated,
and a series of mechanistic studies were performed.