Clearance of multiple cutaneous warts by targeting a single lesion: a randomized comparative evaluation of mild local hyperthermia versus cryotherapy

Supplement I. Protocol of the trial
Supplement II. Medical Instruments
A plantar wart patient is receiving treatment with a hyperthermia medical instrument, and a 2 cm diameter red facula is the treatment spot.
Supplement III. Time course of the treatment and evaluation points.
Participants were randomly assigned to receive hyperthermia at a temperature of 44±2°C for 30 min on days 1, 2, 3, 17, 18, 25, and 32 and cryotherapy on days 1, 14, and 28 on a single target lesion. At each time visit, the patient was assigned to a blinded evaluator to evaluate the status of all the lesions.
Supplement V. Representative clinical pictures of multiple plantar warts cleared in the two groups.
The red circles show target lesions, and the blue arrows delineate nontarget lesions. The blue rectangle that is highlighting pictures in the cryotherapy group shows a remote subungual wart under the patient's thumbnail.

补充一：试验方案
补充二：医疗仪器
一例跖疣患者正在使用高温医疗仪器进行治疗，治疗区域为一个直径为2厘米的红色斑点。
补充三：治疗过程及其评估节点。
参与者被随机分配接受44±2°C的高温治疗，每次持续30分钟，分别在1日、2日、3日、17日、18日、25日和32日进行，以及在第1日、14日和28日对单个目标病变进行冷冻治疗。在每次就诊时，患者将被分配给一位盲法评估员，以评估所有病变的状态。
补充五：两组中多发性跖疣清除的典型临床图片。
红色圆圈标记了目标病变，蓝色箭头划定了非目标病变。在冷冻治疗组中，突出显示的蓝色矩形区域展示了患者指甲下的远端甲下疣。