Discovery and Characterization of the Tuberculosis Drug Lead Ecumicin
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/Discovery_and_Characterization_of_the_Tuberculosis_Drug_Lead_Ecumicin/2228251
下载链接
链接失效反馈官方服务：
资源简介：
The new tuberculosis (TB) lead ecumicin
(1), a cyclic
tridecapeptide, was isolated from Nonomuraea sp. MJM5123,
following a high-throughput campaign for anti-TB activity. The large
molecular weight of 1599 amu detected by LC-HR-MS precluded the initial
inference of its molecular formula. The individual building blocks
were identified by extensive NMR experiments. The resulting two possible
planar structures were distinguished by LC-MS2. Determination
of absolute configuration and unambiguous structural confirmation
were carried out by X-ray crystallography and Marfey’s analysis.
创建时间：
2016-02-16
