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Total Synthesis of (±)-Dragmacidin E

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NIAID Data Ecosystem2026-03-07 收录
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The bis indole sponge alkaloid dragmacidin E was synthesized in racemic form over 25 steps starting from 7-benzhydroxyindole. Key steps include (a) a Witkop cyclization to facilitate construction of the indole-spanning seven-membered ring and (b) a cyclodehydrative pyrazinone synthesis that unites the two indole-containing sectors.

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2016-02-22
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