Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

NIAID Data Ecosystem2026-03-13 收录

结直肠癌代谢机制

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE200910 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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2022-08-03

Z-scores outperform similar methods for analyzing CRISPR paralog synthetic lethality screens

CRISPRi

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Genetic screens offer a promising strategy for identifying tumor-specific therapeutic targets, but single-gene knockout screens often miss functionally redundant paralogs. Multiplex Cas9 and Cas12a CR

DataCite Commons2025-07-03 更新110

Gene expression of SLNs (Synthetic Lethal with Nutlin-3) on HCT116 cells

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癌症药物响应

A subset of our SLNs would be upregulated by Nutlin-3 and down-regulated by 5-FU and that this differential regulation could potentially explain how cell fate choice is determined SLNs as a group were

NIAID Data Ecosystem60

2019_Synthetic_lethal_interaction_of_SHOC2_depletion_with_MEK_inhibition_in_RAS_driven_cancers

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RAS驱动癌症治疗

This dataset contains supporting data for "Synthetic lethal interaction of SHOC2 depletion with MEK inhibition in RAS-driven cancers", Cell Reports (2019).Contents:genomewide.chip: Alignment file for

Figshare2019-08-13 更新50

Stable overexpression and knockdown of mutant- or wild type SPOP in VCaP prostate cancer cells. Stable overexpression and knockdown of mutant- or wild type SPOP in VCaP prostate cancer cells

前列腺癌基因互作

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Purpose: Little is known about the interplay of driver mutations that never co-occur within the same cancer cells. The latter scenario has been identified in prostate cancer where recurrent gene fusio

NIAID Data Ecosystem100

Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma

淋巴瘤靶向治疗

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Knowledge of essential oncogenic mutations can inspire therapeutic strategies that are synthetically lethal, affecting cancer cells bearing an oncogenic mutation while sparing normal cells. Lenalidomi

NIAID Data Ecosystem50

Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

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