Tetrameric POLQ Helicase-like Domain Bound to Cmpd 36, a Small-Molecule ATPase Inhibitor and Drug Candidate Analog

Tetrameric POLQ Helicase-like Domain Bound to Cmpd 36, a Small-Molecule ATPase Inhibitor and Drug Candidate Analog Descriptor: (2P)-N-[5-(cyclopropylethynyl)-1,3,4-thiadiazol-2-yl]-2-[2-(difluoromethyl)-5-methoxypyridin-4-yl]-4-[(4-hydroxyoxan-4-yl)ethynyl]benzamide, DNA polymerase theta Authors: Zahn, K.E, Mader, P, Sicheri, F. Deposit date: 2025-05-26 Release date: 2025-09-17 Last modified: 2025-10-01 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Pol theta ATPase Inhibitor. J.Med.Chem., 68, 2025