Characterization of murine non-hematopoietic Gli1+ bone marrow cells in homeostasis
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE156440
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资源简介：
We performed fate tracing of Gli1+ cells in homeostasis. Sorted cells were subjected to scRNAseq and integrated with non-hematopoietic cells from mice with myelofibrosis induced by either ThPO- or JAK2V617F-overexpression. Gli1+tdTom+ cells largely overlap with pro-fibrotic adipogenic and osteogenic MSCs, which show a strong upregulation of ECM related transcripts. Additionally, a subgroup of Gli1+tdTom+ cells shows similarity with bone marrow SCPs. We used scRNA 3' RNA sequencing product from 10x Genomics to profile murine Gl1+tdTom+ non-hematopoietic bm cells in homeostasis.
创建时间：
2021-02-02
