Metal-Free C–H Functionalization of Allenamides: An Access to Branched Allylic Esters

A regioselective
acyloxylation with carboxylic acids at the proximal
carbon of allenamides by an N-iodosuccinimide-mediated
C–H functionalization is reported. The reaction proceeds rapidly,
is scalable to a gram scale, and displays a broad substrate scope,
providing an efficient and practical protocol for the synthesis of
branched allylic esters. Notably, protected amino acids were tolerated
under the reaction conditions and afforded allylic amino acid esters
in moderate yields.