Additional file 2 of Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes

Additional file 2: Supplementary Tables. Table 1 Genetic correlation between reproductive factors using linkage disequilibrium score regression. Table 2 Instrument strength across multivariable mendelian randomization analyses. Table 3 Mendelian randomization results for the effect of ever parous status on breast cancer risk. Table 4 Mendelian randomization results for the effect of age at first birth on breast cancer risk. Table 5 Mendelian randomization results for the effect of age at last birth on breast cancer risk. Table 6 Mendelian randomization results for the effect of number of births on breast cancer risk. Table 7 Univariable mendelian randomization results for the effects of ever parous status, age at first birth, age at last birth and number of births on breast cancer risk across methods MR Egger, weighted median and weighted mode. Table 8 MR PRESSO results for the effects of ever parous status, age at first birth, age at last birth and number of births on breast cancer risk. Table 9 Egger intercept results for the effects of ever parous status, age at first birth, age at last birth and number of births on breast cancer risk. Table 10 Test for heterogeneity for the multivariable analysis of ever parous status, age at first birth, age at last birth and number of births on breast cancer risk. Table 11 Multivariable mendelian randomization results for the effects of ever parous status, age at first birth, age at last birth and number of births on breast cancer risk using the MR Egger method. Table 12 Association between SNPs robustly associated with ever parous status, and ever parous status and breast cancer risk. Table 13 Association between SNPs robustly associated with age at first birth, and age at first birth and breast cancer risk Table 14 Association between SNPs robustly associated with age at last birth, and age at last birth and breast cancer risk. Table 15 Association between SNPs robustly associated with number of births, and number of births and breast cancer risk.