Nodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance

Herein, we demonstrated Nodal overexpression in CRC, which was associated with CRC progression and metastasis. More importantly, Nodal induced ferroptosis resistance and promoted cancer cell survival and metastasis by up-regulating downstream SCD1. Gene therapy targeting Nodal was found to be highly effective in vivo and in vitro for treating CRC, thereby highlighting the translational potential of Nodal as a new strategy for CRC therapy.