Crystal structure of KPC-2 S70G/T215P mutant with hydrolyzed meropenem
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Crystal structure of KPC-2 S70G/T215P mutant with hydrolyzed meropenem Descriptor: (2S,3R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfan yl-3-methyl-2,3-dihydro-1H-pyrrole-5-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC Authors: Furey, I, Palzkill, T, Sankaran, B, Hu, L, Prasad, B.V.V. Deposit date: 2021-02-03 Release date: 2021-05-26 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 beta-lactamase. J.Biol.Chem., 296, 2021
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2021-02-03
