Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice

The main objective of this study was to investigate the potential probiotic properties of Lacticaseibacillus rhamnosus VHProbi M15. The structure of intestinal flora was analyzed by 16SrRNA high-throughput sequencing, and the effect of M15 on the intestinal flora of sucralfate induced constipation mice was analyzed. Analysis of the intestinal microbiota of mice revealed an increase in the relative abundance of Bacteroides and a decrease in Sclerotinia, Verrucosa and Proteus in M15 group.Compared with the constipation group, the constipation-induced intestinal microecological changes were partially recovered in positive and probiotic groups.