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Improving the sensitivity of in vivo CRISPR off-target detection through DNA repair inhibition. Homo sapiens and Mus musculus

NIAID Data Ecosystem2026-03-13 收录

CRISPR脱靶检测

基因编辑安全性

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA801688 数据链接链接失效反馈

官方服务：

资源简介：

Improving the sensitivity of in vivo CRISPR off-target detection through DNA repair inhibition

应用场景：

创建时间：

2022-01-28

基因编辑安全性

核酸酶脱靶检测

We describe a robust linear amplification-mediated high-throughput genome-wide translocation sequencing (HTGTS) method that identifies endogenous or ectopic "prey" DNA double-stranded breaks (DSBs) ac

NIAID Data Ecosystem60

Number of GUIDE-seq datasets and identified digested sequences. The numbers in the parentheses include technical replicates.

CRISPR脱靶检测

基因编辑序列分析

Number of GUIDE-seq datasets and identified digested sequences. The numbers in the parentheses include technical replicates.

Figshare2025-07-18 更新40

Gene editing of colocalized NCF1 loci is associated with homologous recombination and chromosomal rearrangements - CAST-seq

基因编辑安全性

慢性肉芽肿病基因治疗

Despite lingering genotoxicity concerns, CRISPR-based genome editing has progressively entered the gene therapy field. Here we report that interactions between nucleotide sequences that are localized

NIAID Data Ecosystem10

Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites

基因编辑安全性

逆转录转座子转录

CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology and entered the clinical world for targeted gene therapy. Identifying DNA modifications occurring at CRISPR/Cas9 targ

NIAID Data Ecosystem40

Additional file 1 of Deep learning improves the ability of sgRNA off-target propensity prediction

CRISPR脱靶预测

基因编辑安全性

Additional file 1. Detailed comparison results for sgRNA off-target propensity prediction.

Figshare2020-02-11 更新30