Crystal structure of IDH1 R132H in complex with HMS101
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Crystal structure of IDH1 R132H in complex with HMS101 Descriptor: (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine, Isocitrate dehydrogenase [NADP] cytoplasmic Authors: Chaturvedi, A, Goparaju, R, Gupta, C, Kluenemann, T, Araujo Cruz, M.M, Kloos, A, Goerlich, K, Schottmann, R, Struys, E.A, Ganser, A, Preller, M, Heuser, M. Deposit date: 2018-12-10 Release date: 2019-10-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.3 Å) Cite: In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site. Leukemia, 34, 2020
创建时间：
2018-12-10
