Goal: The goal of this study was to compare gene induction in old and young human monocytes upon stimulation of these cells with a RIG-I specific ligand, based on previously published results which in

NIAID Data Ecosystem60

Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis

内脏利什曼病疫苗

免疫衰老

Background Visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania donovani causes severe disease. Age appears to be critical in determining the clinical outcome of VL and at present t

NIAID Data Ecosystem50

Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans. Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans

免疫衰老

CD8+T细胞衰老

Aging leads to a progressive functional decline of the immune system, rendering the elderly increasingly susceptible to disease and infection. The degree to which immune cell senescence contributes to

NIAID Data Ecosystem60

Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands

免疫衰老

泪腺免疫学

Aging is associated with a massive infiltration of T lymphocytes in the lacrimal gland. . Among the non-Tregs, we also found a significant increase in the levels of EOMESmed/high, TbetnegIFN-𝛄+ and C

NIAID Data Ecosystem50

RNA sequencing of SNA-high and -low, young and old murine T cells.

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