Bgee DataBase for Gene Expression Evolution

Bgee is a database for retrieval and comparison of gene expression patterns across multiple animal species. It provides an intuitive answer to the question "where is a gene expressed?" and supports research in cancer and agriculture as well as evolutionary biology. Bgee data are produced from multiple data types (bulk and single-cell RNA-Seq, Affymetrix, in situ hybridization, EST data), and multiple data sets, that are all integrated consistently to provide a single answer to the question: "where is this gene expressed?" Bgee is based exclusively on curated "normal", healthy wild-type expression data (e.g., no gene knock-out, no treatment, no disease), to provide a comparable reference of normal gene expression. Bgee produces calls of presence/absence of expression, and of differential over-/under-expression, integrated along with information of gene orthology, and of homology between organs. This allows comparisons of expression patterns between species.

Bgee是一款用于检索并对比多种动物物种基因表达模式的数据库。它能够直观解答"基因在何处表达"这一问题，同时可为癌症、农业以及进化生物学领域的研究提供支持。
Bgee的数据来源于多种数据类型（批量RNA测序、单细胞RNA测序、Affymetrix芯片、原位杂交、表达序列标签（Expressed Sequence Tag，EST）数据）与多组数据集，所有数据均经过统一整合，以精准回答"该基因在何处表达"这一单一问题。
Bgee仅采用经人工审编的"正常"健康野生型表达数据（例如无基因敲除操作、无外源处理、无疾病状态的样本），旨在提供具备可比性的正常基因表达参考数据集。
Bgee可生成表达存在/缺失以及表达差异上调/下调的判定结果，并将这些结果与基因直系同源性、器官间同源性信息进行整合，从而实现跨物种的基因表达模式对比。

搜集汇总

背景与挑战

背景概述

Bgee是一个专注于动物基因表达数据检索与比较的数据库，整合了多种数据类型（如RNA-Seq、原位杂交等），以提供基因在正常健康状态下的表达信息。它支持跨物种表达模式分析，并服务于癌症、农业及进化生物学等领域的研究。