Ancestral beta-globin gene haplotypes modify beta-thalassemia severity in a mouse model [Ery]

beta-Thalassemia is a prevalent anemia caused by mutations in the HBB (beta-globin) gene. We show that the severity of beta-thalassemia in the frequently studied Hbb(th3/+) mouse model is influenced by ancestral beta-globin gene (Hbb) haplotypes that differ in common strains. Overall design: Gene expression profiling of RNA-Seq data from 4 single Hbb and 4 diffuse Hbb mice. Profiling was done on freshly sorted murine peripheral blood reticulocytes and bone marrow CD71hiFSChi (Ery. A) and CD71hiFSClo (Ery. B) cells.