Scalable Total Synthesis of (−)-Vinigrol

Vinigrol is a structurally
and stereochemically complex natural
product that displays various potent pharmacological activities, including
the capability to modulate TNF-α. A new and efficient synthetic
route toward this natural product has been developed to complete the
asymmetric synthesis of (−)-vinigrol and provide over 600 mg
of material, manifesting the power of macrocyclic stereocontrol and
transannular Diels–Alder reaction.