single cell RNA sequencing of early lung adenocarcinoma from never smoker.. Homo sapiens

Lung cancer is the leading cause of cancer-related death, and the majority of lung cancers are directly or indirectly related to smoking. In recent years, lung cancer in nonsmokers has ranked among the top 10 causes of cancer deaths in both men and women and significantly differs in pathogenesis and clinical aspects from lung cancer in smokers. Adenocarcinoma is the most dominant histology in lung cancer in nonsmokers, and early lung adenocarcinoma in nonsmokers often presents in the form of ground-glass nodules on chest CT scans. To study early lung carcinogenesis and changes in the tumor microenvironment of nonsmoker, early lung adenocarcinomas in the form of GGNs were explored by single-cell transcriptomic analysis and compared with corresponding adjacent normal-appearing nonmalignant lung tissues.