Synthesis,Spectral Characterization and Antimicrobial Screening of Novel Quinoxaline Incorporated Dibenzo[b,f] [1,4] Thiazepine Derivatives

A novel series of quinoxaline derivatives incorporating dibenzo[b,f][1,4]thiazepine moiety were synthesized through cyclization of chalcone intermediates with o-phenylenediamine under acidic conditions. 13 The synthesized compounds were characterized by IR, 1H NMR and Mass spectral studies. 4 The antimicrobial activity of synthesized compounds was evaluated against gram-positive bacteria, gram-negative bacteria and fungal strains using cup-plate diffusion method at 50 µg/mL concentration. 5 Compounds bearing methoxy, nitro and amino substituents exhibited promising biological activity. The synthesized derivatives demonstrated moderate to significant antimicrobial properties compared with standard drugs such as ampicillin, chloramphenicol, norfloxacin and griseofulvin. Keywords: Quinoxaline, Dibenzo[b,f][1,4]thiazepine, Antimicrobial activity, Spectral study, Chalcones.