Asymmetric Synthesis of Oxindole-Derived Vicinal Tetrasubstituted Acyclic Amino Acid Derivatives by the Mannich-Type Reaction
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https://figshare.com/articles/dataset/Asymmetric_Synthesis_of_Oxindole-Derived_Vicinal_Tetrasubstituted_Acyclic_Amino_Acid_Derivatives_by_the_Mannich-Type_Reaction/12642126
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资源简介：
The catalytic asymmetric
Mannich-type reaction of 3-hydroxy/3-aminooxindoles
with 2-aminoacrylates to afford oxindole-derived acyclic amino acid
derivatives bearing vicinal tetrasubstituted stereocenters is reported.
(DHQ)2PHAL (4g) and quinine-derived squaramide
(4d) were identified as efficient catalysts. Transformations
of the Mannich-type reaction products highlight the utility of this
synthetic strategy.
创建时间：
2020-06-30
