Identification of lncRNA and mRNA expression profile of relapsed Graves' disease

Graves' disease (GD) is a common autoimmune disease, and its pathogenesis is unclear. Studies have found that the occurrence of GD is related to the immune disorder caused by the interaction of genetic susceptibility and environmental factors. The CD4+T cell subset is closely related to the immune disorder of GD. LncRNAs are RNA molecules with a length of more than 200 nt and invovled in a variety of autoimmune diseases. The study about lncRNAs in recurrent GD is still blank. The purpose of this study is to identify lncRNA and mRNA expression profile and eatablish a new five-gene diagnostic model for relapsed GD.CD4+ T cells from 12 recurrent GD and 8 healthy controls were collected for high-throughput sequencing. The gene-weighted co-expression network analysis (WGCNA) is used to construct the co-expression module relevant to recurrent GD , and the key genes in the module are verified by RT-PCR.