Mouse papillomavirus methylation signature is characterized by hypermethylation and retention of viral memory after lesion regression

We sought to describe the global methylation landscape of mouse papillomavirus (MmuPV1) in the context of active and regressed MmuPV1 lesion tissue Mice that were immune-suppressed using the drug Cyclosporin (CsA) were infected with MmuPV1 on their tails. Wart lesions developed and the skin of these lesions was harvested (Active group), or allowed to heal by withdrawing CsA and then harvested (Regressed group). Reduced Representation Bisulphite Sequencing (RRBS) was used to compare methylation patterns between the groups and their controls