Circular RNA profile of steroid-induced osteonecrosis of the femoral head

Circular RNAs (circRNAs) represent a widespread class of non-coding RNAs, which drew little attention in the past. Recently, limited data showed their promising future to act as biomarkers in human diseases, but the characteristics and functions remain largely unknown in steroid-induced osteonecrosis of the femoral head. In this study, with the help of circRNA sequecing, we demonstrated the expression profile of circRNAs in steroid-induced osteonecrosis of the femoral head patients, and identified a large number of circRNAs. We also described a circRNA signature related to steroid-induced osteonecrosis of the femoral head based on the bioinformatics prediction.