Dosing schedules considered in the comparison of single-agent and combination therapies.

Each lettered column denotes a distinct dosing schedule containing repeating 3-week cycles defined by the dosing protocols in that column. The entries with subscripts of 1 are doses of erlotinib in mg and the entries with subscripts of 2 are doses of evofosfamide in mg/m2. For a fixed schedule (column) and day (row), a single entry represents the one dose of either erlotinib or evofosfamide scheduled for that day. A missing entry for a fixed schedule and day corresponds to a day with neither erlotinib nor evofosfamide. Two entries for a given schedule on a single day represent the scheduling of two doses, either one dose of each drug or two doses of the same drug.