Global directional changes in miRNA and protein expression induced by CIE paradigm.

A-F are named as in Figure 1. N. DE, number of differentially expressed molecules with fold change >5% or % DE, percentage of differentially expressed molecules based on their total number (1,023 miRNAs and 2,369 protein spots detected); % ↑ and % ↓, percentages of up- and down-regulated molecules; Paired Exp., paired expression between miRNAs and protein spots in the same brain region and comparison. Overall directional changes in miRNA (microarrays) and protein spot (2D-DIGE) expression for each comparison and brain region analyzed. Comparisons