Dermatan sulfate biosynthesis

Dermatan sulfate (DS) consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. As with CS, GalNAc residues can be sulfated in CS chains but also the uronic acid <br>residues may be substituted with sulfate at the 2- and 4- positions. The steps below outline the synthesis of a simple DS chain (Silbert & Sugumaran 2002).硫酸皮肤素（DS）由N-乙酰半乳糖胺（GalNAc）残基交替连接于葡萄糖酸（GlcA）或艾杜糖酸（IdoA）残基的糖苷键中构成。与硫酸软骨素（CS）类似，GalNAc残基可被硫酸化，形成CS链，同时尿苷酸残基亦可能在2-和4-位被硫酸根取代。以下步骤概述了简单DS链的合成过程（Silbert & Sugumaran, 2002）。