Iridium-Catalyzed Regio- and Enantioselective C7-Allylic Alkylation of 4‑Aminoindoles

The first iridium-catalyzed direct intermolecular indole C7-allylic alkylation of 4-aminoindoles and racemic branched allylic esters was reported. Various substituted substrates were applicable to give the corresponding C7-allylated products in moderate to high yields (43–80%) with high regio- and enantioselectivities (82–99% ee) under mild reaction conditions. Representative transformations of the vinyl group in the product were carried out to examine the utility of this protocol.