ATAC-Seq profiling of progenitor exhausted and terminally exhausted CD8+ T-cells from tumors and chronic viral infection

Epigenetically similar subpopulations of exhausted CD8+ T-cells are found in chronic viral infection and tumors Overall design: ATAC-Seq analysis of progenitor exhausted and terminally exhausted CD8+ T-cells isolated from spleens of mice chronically infected with LCMV Clone 13 (day 30 post-infection) or isolated from B16-ova tumors (day 22 post tumor implantation), with or without anti-PD-1 treatment Peak-calling was performed on merged bams and the data is linked to the first replicate records.