AICD transgenic mice show decreased cell proliferation in the SGZ of hippocampus.

Representative images of BrdU immunostaining in the subgranular zone (SGZ) of the dentate gyrus performed on 1.5-mont-old (A) 3-month-old (C) and 12-month old (D) wild-type and FeCγ25 animals one day after the final BrdU injection (100 mg/kg). (A–B) At 1.5 mo there was no statistically significant difference in the number of BrdU-labeled cells between wild-type and FeCγ25 mice, quantified in (B). (E) Quantitative analysis of the total number of BrdU+ cells throughout the entire rostro-caudal extent of the hippocampus in 3-month-old (top) and 12-month-old (bottom) animals reveal a statistically significant decrease in the number of BrdU+ cells in the SGZ of FeCγ25 mice compared to wild-type mice. (n = 3, 4 and 4 for both wild-type and FeCγ25 mice at ages 1.5 mo, 3 mo and 12 mo respectively. n = 3 for Fe27 mice at 3 mo. * p<0.05, ** p<0.01).