Dichloroacetate and reduced oxygen utilization induced metabolic regulation of the heart: A focus on the cardiac mitochondrial proteome

Myocardial compensatory mechanisms stimulated by reduced oxygen utilization caused by streptozotocin-induced diabetes mellitus (D) and treated with the dichloroacetate (DCA) are presumably associated with the regulation of mitochondria. We aimed to promote the understanding of key signaling pathways and identify effectors involved in signal transduction.