Impact of anti-CD40 treatment on mouse livers

Treating samples with anti-CD40, and antibiotics to establish what transcriptional impact antibiotics is having. Anti-CD40 was found to induce a strong inflammatory signature. Antibiotics in combination with anti-CD40 attenuated this resulting in a much improved phenotype. However the detectable transcriptional differences were somewhat modest. Overall design: 20 samples in total. 5 per group. 4 groups, which are Control. Contorl + ABX. Anti-CD40, Anti-CD40 + ABX. All are from individual mice. No longitudinal measurements.