An Access to Aza-Freidinger Lactams and <i>E</i>‑Locked Analogs
收藏NIAID Data Ecosystem2026-03-07 收录
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Freidinger lactams, possessing a peptide bond configuration locked to Z, are important key elements of conformationally restricted peptidomimetics. In the present work, the CαHi+1 unit has been replaced by N, leading to novel aza-Freidinger lactams. A synthesis to corresponding building blocks and their E-locked analogs is introduced. The versatile buildings blocks reported here are expected to serve as useful elements in peptide synthesis.
创建时间：
2013-02-01
