RNA binding protein-mediated RNA turnover contributes to the RNA abundance.. Homo sapiens

By integrative analysis of ChIP-seq, RNA-seq and our BRIC-seq, we found that transcriptional regulation and RNA degradation are independently regulated. In addition, we showed that RNA stability serves as an important determinant of eventual transcript levels. We also suggest that RNA binding proteins, such as UPF1, STAU1 and EXOSC5, play active roles in such controls.