Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities: discovery cohort meta data and parsed TCR repertoire data
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https://zenodo.org/record/5719519
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Meta data corresponding the the discovery cohort for the paper, "Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities" by Magdalena L Russell, Aisha Souquette, David M Levine, Stefan A Schattgen, E Kaitlynn Allen, Guillermina Kuan, Noah Simon, Angel Balmaseda, Aubree Gordon, Paul G Thomas, Frederick A Matsen IV, and Philip Bradley. These meta data include:
(1) a file mapping the SNP data subject IDs to the TCR repertoire data subject IDs (gwas_id_mapping.tsv)
(2) a file including the PCAir PCs, self-reported ancestry, and genomic ancestry for each subject (all_pc_air.txt)
(3) a file including the PCAir variance explained by each PC (all_pc_air_variance.txt)
(3) a file including the SNP ID, chromosome, hg19 position, allele, rsid, and quality control metrics for each SNP in the SNP array (emerson_snp_rs_data.tsv)
(4) a file including IMGT genes and sequences used for parsing TCRB repertoire data (human_vj_allele_cdr3_nucseqs.tsv)
(5) a file including predicted TRBD2 allele genotypes for each subject (emerson_trbd2_alleles.tsv)
(6) Parsed TCRB repertoire data. These raw data were first published in Emerson et. al, Nature Genetics 2017. (emerson_parsed_tcrb.tgz)
Corresponding discovery cohort raw TCR repertoire data is available here: https: //doi.org/10.21417/B7001Z (ImmuneACCESS database)
Corresponding discovery cohort SNP data is available here: https: //www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001918.v1.p1 (The database of Genotypes and Phenotypes, accession number: phs001918)
Software tools designed to work with these data are available here: https://github.com/phbradley/tcr-gwas
创建时间:
2021-12-23



