Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α‑Amino Ketones
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https://figshare.com/articles/dataset/Asymmetric_Transfer_Hydrogenation_Dynamic_Kinetic_Resolution_of_Amino_Ketones/12830598
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资源简介：
A series of α-amino
ketones were reduced using asymmetric
transfer hydrogenation (ATH) through a dynamic kinetic resolution
(DKR). The protecting group was matched to the reducing agent, and
following optimization, a series of substrates were investigated,
giving products in high diastereoselectivity, over 99% ee in several
cases and full conversion. The methodology was applied to the enantioselective
synthesis of an MDM2–p53 inhibitor precursor.
创建时间：
2020-08-07
