The Landscape of Circular RNA Expression in the Human Brain

The resource comprises of hundreds of novel circRNAs and demonstrate that circRNAs are not expressed stochastically, but rather as major isoforms. It characterises inter-individual variability of circRNA expression in the human brain and show that inter-individual variability is less pronounced than variability between cerebral cortex and cerebellum. They identify a circRNA co-expression module upregulated in autism samples, thereby adding another layer of complexity to the transcriptome changes observed in autism brain. These data provide a comprehensive catalogue of circRNAs as well as a deeper insight into their expression in the human brain, and are available as a free resource.本数据集涵盖数百种新型环状RNA（circRNA），证实环状RNA并非随机表达，而是以主要转录本亚型的形式存在。该研究刻画了人类大脑中环状RNA表达的个体间差异，发现个体间差异较大脑皮层与小脑之间的差异更为微弱。研究团队鉴定出一个在自闭症样本中上调表达的环状RNA共表达模块，由此为自闭症大脑中观测到的转录组变化增添了另一重复杂维度。本数据集提供了一套全面的环状RNA目录，并深入揭示了其在人类大脑中的表达特征，且作为免费资源对外开放。

搜集汇总

背景与挑战

背景概述

该数据集提供了一个人类大脑中环状RNA表达的全面目录，揭示了其非随机表达模式及个体间变异性，并发现了一个在自闭症样本中上调的环状RNA共表达模块，增加了自闭症大脑转录组变化的复杂性。