Electrochemical Oxidative Dearomatization Strategy for Accessing Spiro[4.5]dienones and Derivatives

Electrochemical dearomatization has been recognized as
an attractive
tool for the rapid construction of structurally diverse molecules.
The designed methodology encompasses an eco-friendly and efficient
electrochemical approach to synthesizing spiro[4.5]dienones under
mild reaction conditions. Furthermore, detailed mechanistic studies
strongly bolster our hypothesis and emphasize the role of HFIP in
the mechanism. The protocol is scalable and showcases a broad substrate
scope with tolerance toward numerous functional groups. Henceforth,
this strategy can be deployed as an alternative and sustainable tool
for accessing spiro[4.5]dienones.