Conversion of DHA-CoA to docosahexaenoic acid (DHA)

DHA-CoA preferentially moves back to the ER, perhaps as a free fatty acid. This conversion is usually catalysed by acyl-CoA thioesterases (ACOTs). No specific acyl-CoA thioesterase enzyme has been identified for the peroxisomal metabolism of DHA-CoA, but the peroxisomal ACOT8 has a wide substrate specificity and is likely to be responsible (Ferdinandusse et al. 2003, Hunt & Alexson. 2008).

DHA-CoA优先逆向转移至内质网，或许作为游离脂肪酸存在。此转化过程通常由酰基辅酶A硫酯酶（ACOTs）催化。尚未鉴定出针对过氧化物酶体中DHA-CoA代谢的特定酰基辅酶A硫酯酶酶，但过氧化物酶体中的ACOT8具有广泛的底物特异性，并可能承担此责任（Ferdinandusse等，2003年；Hunt & Alexson，2008年）。