Seven nucleotide mutations of HBx sequences were independent risk factors for genotype C HBV-related HCC.

aMutated nucleotides are shown in bold.B cell epitope: region (aa positions 29–48); BH3-like motif: region (aa positions 116–132); Box α, region (nt1646-1668); C/EBP, CCAAT/enhancing binding protein, region (nt1643-1658); CP, core promoter, region (nt1613-1849); Enh2: enhancer 2, region (nt1636-1744); HNF3, hepatocyte nuclear factor 3, region (nt1713-1723); NRE, negative regulatory element, region (nt1611-1634); T-cell epitope: region (aa positions 116–127).Seven nucleotide mutations of HBx sequences were independent risk factors for genotype C HBV-related HCC.