Single Gene Distribution Variability.

These data show deviation from the parameters of a Gaussian distribution for the standard deviations (σ), skewness, and kurtosis of the expression distributions of individual genes comprising the cancer expression datasets. If the assumption that individual gene expression distributions are Gaussian were correct, then the mean σ should approximate 1, the mean skewness should approximate 0, and the mean kurtosis should approximate 3. The deviations from these theoretical parameters exhibited by the individual gene expression distributions in all five cancer datasets refute the Gaussian assumption for individual genes.