The effect of T/B cell maturation deficiency on the pulmonary pathology of acute SARS-CoV-2 infection

To investigate the function T and B cells in SARS-CoV-2 infection, we utilized Rag2-/- mice and infected them with a mouse adapted strain of SARS-CoV-2 virus (MA30) We then performed gene expression analysis using data obtained from RNA-seq of the lungs of 3 Rag2+/+ and 3 Rag2-/- mice at 3 days post-infection (DPI) with MA30. Comparative gene expression analysis of RNA-seq data for 3 Rag2+/+ (WT) and 3 Rag2-/- (KO) mice at 3 DPI using MA30 1×104 TCID50