SingleBrain: Single-nucleus Trans Expression QTL Meta-analysis Summary Statistics across Multiple Human Brain Cohorts

https://github.com/RajLabMSSM/SingleBrain Bonferroni significant association summary statistics for trans-eQTLs mapped in a meta-analysis across multiple human brain single-nucleus RNA seq cohorts, as part of the "SingleBrain" project. Sample size = 983 European ancestry donors from 757 unique donors 4 cohorts (Fujita et al., Mathys et al., Bryois et al., Gabitto et al.) meta-analyzed using the linear mixed model random-effects meta-analysis software mmQTL (PMID: 35058635). Number of tested SNPs = 265,814 Bonferroni threshold = 0.05/(#genesTested x #variantsTested) Each file has the following naming convention: {Cell type}_trans_eqtl_peak_1_sig_assoc.tsv.gz References The following reference was used for mapping phenotypes: 1. GENCODE - GENCODE v38 comprehensive transcripts (https://www.gencodegenes.org/human/release_38.html) Cell type The following brain 6 major cell types were tested for genetic association: Ast: astrocytes Ext: excitatory neurons IN: inhibitory neurons MG: microglia OD: oligodendrocytes OPC: oligodendrocyte progenitor cell All phenotype matrices were scaled and centered and then quantile normalized. Data dictionary feature: the phenotype being tested variant_id: the genetic variant being tested chr: chromosome pos: position (hg38) ref: reference allele alt: alternate allele fixed_beta: Fixed effect meta-analysis estimate of the beta fixed_sd: Fixed effect meta-analysis standard error of the beta fixed_z: Fixed effect meta-analysis Z-score Fixed_P: Fixed effect meta-analysis P-value Random_Z: Random effect meta-analysis Z-score Random_P: Random effect meta-analysis P-value cis_feature: cross-mappable gene pair with feature crossmap: cross-mappable gene pairs estimated using Saha et al.[PMID: 30613398] are filtered less than 5.