Aspergillus nidulans dynamic transcriptome during synchronized conidiation

The dynamic transcriptome of A. nidulans during synchronized conidiation has over 2500 gene products show differential expression, including transcripts for both brlA and abaA, which increase steadily over time. In contrast, GSE136562, a dynamic transcriptomic response taken during wall-stress induced by the echinocandin micafungin, the brlA transcript is upregulated while the abaA transcript is not. In addition, when mpkA (last protein kinase in the cell wall integrity signaling pathway) is deleted, brlA expression is not upregulated in response to wall stress. Together, these data imply BrlA may play a role in a cellular stress-response which is independent of the canonical BrlA-mediated conidiation pathway. Synchronous asexual development of Aspergillus nidulans was initiated via growth of mycelia from the air/liquid interface. Samples were taken at 0, 6, 12, 18, 24, 30 and 48 hours after the initiation of asexual development. *************************************************************** Raw data files were lost ***************************************************************