Kinetic parameters of OATP1B1 wild-type and its mutants for high concentrations of E-3-S.
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Uptake of E-3-S was measure at concentrations of 5 µM, 20 µM, 50 µM and 100 µM at a 1-min interval for OATP1B1 and its mutants. Transport kinetic values were calculated using the Eadie-Hofstee transformation. The results shown are means ± S.E. (n = 3). Asterisks indicate values significantly different (p<0.05) from that of OATP1B1 wild-type.
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2015-12-02
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