Brazilian High Risk Cohort Study (BHRC)
收藏资源简介：
The Brazilian High Risk Cohort Study for Childhood Psychiatric Disorders (BHRC) is a large community school-based study that is following 2,511 children from Brazil since 2010. We obtained psychological, genetic, and neuroimaging data with the aim to investigate typical and atypical trajectories of psychopathology and cognition over development. We used a two-stage design. We first assessed childhood symptoms and family history of psychiatric disorders in a screening interview, collecting information from 9,937 index children at 57 schools in the cities of São Paulo and Porto Alegre, as well as from 45,394 family members. In the second stage, a random subsample (intended to be representative of the community, n = 958) and a high-risk subsample (children at increased risk for mental disorders, based on family risk and childhood symptoms, n = 1554) were selected for further evaluation. We evaluated those 2,511 subjects using an extensive protocol, involving one 2-h home evaluation with the parents, two 1-h evaluations of the child by a psychologist, and two 1-h evaluations of the child by a speech pathologist. In those evaluations, saliva samples for genetic studies were collected from the subjects and their biological parents. In addition, 750 children were invited to take part in a neuroimaging study and to provide blood samples for the assessment of peripheral blood biomarkers. Those children were collectively designated the enriched imaging cohort. We just completed our 3-year follow up with 80% retention.
巴西儿童精神疾病高风险队列研究（Brazilian High Risk Cohort Study for Childhood Psychiatric Disorders, BHRC）是一项大型社区校园队列研究，自2010年起对巴西2511名儿童开展长期追踪随访。本研究收集心理、遗传与神经影像数据，旨在探究发育进程中精神病理与认知的典型及非典型发展轨迹。 本研究采用两阶段研究设计。第一阶段通过筛查访谈评估儿童精神症状与精神疾病家族病史，共从圣保罗与阿雷格里港两市的57所学校招募9937名索引儿童，并收集45394名家庭成员的相关信息。第二阶段，研究基于社区代表性随机抽取亚样本（n=958），以及结合家族风险与儿童症状评估为精神疾病高风险的亚样本（n=1554），共计2511名受试者进入后续测评环节。研究团队采用全面的测评方案对该2511名受试者进行评估，具体包括：与家长开展一次时长2小时的居家访谈、由心理学家为儿童完成两次1小时的测评、以及由言语治疗师为儿童完成两次1小时的测评。测评期间，采集受试者及其亲生父母的唾液样本用于遗传研究。此外，另有750名儿童受邀参与神经影像研究，并提供血液样本以检测外周血生物标志物，该亚队列被命名为强化影像队列。 目前本研究已完成第三年随访，受试者留存率达80%。
