Mutations in CDRs and FRs before and after the panning selection.
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a Percentage of the designed CDR sequences in total unselected or selected CDR sequences.b Average number of mutations from the closest germline CDR sequence or the reference framework sequence per amino acid position.cP > 0.15 between the values for selected and unselected CDR sequence.dP e Designed CDR-H3 sequences have no germline ancestors.Mutations in CDRs and FRs before and after the panning selection.
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2015-12-03



